It usually hurts so much whenever my daughter's monthly period comes. She can't move freely and she would rather stay at home during her heavy days. Even with the help of over the counter pills, she still feels uncomfortable. Then my sister sent her a bottle of progesterone cream to relieve her of PMS. She said it is the safest and most effective method of progesterone application. With this, she felt no pain and it worked really fast. Now I have to ask my sister to send her more.