I'm not sure if you've heard of this popular belief, but it's only recently that I heard about it also, trying to quell pimples and blackheads with toothpaste. I googled it and found out that it is not a smart move to do so because the flouride in toothpaste can actually cause more breakouts. Plus, some toothpastes contain bleaching and whitening agents which can aggravate your skin's condition. The best way to get rid of blackheads and pimples is to use an acne product that contains benzoyl peroxide, which kills bacteria or salicylic acid, which unclogs pores. Or if you want to get the rid of them natural way, tea tree oil is one to try.